Using Promethazine with Codeine Oral Option in sufferers with acute or extreme bronchial asthma within an unmonitored placing or inside the absence of resuscitative equipment is contraindicated [seeCONTRAINDICATIONS (four)]. Opioid analgesics and antitussives, like codeine, one of several active substances in Promethazine with Codeine Oral Resolution, should not be Employed in individuals with acute febrile health issues affiliated with productive cough or in people with Continual respiratory illness where by interference with capability to clear the tracheobronchial tree of secretions might have a deleterious effect on the client's respiratory purpose.

Utilization of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with Promethazine with Codeine Oral Remedy requires watchful thought of the effects to the guardian drug, codeine, plus the Lively metabolite, morphine.

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Promethazine and Respiratory Depression in Little ones: Postmarketing cases of respiratory despair, which include fatalities, happen to be documented with usage of promethazine in pediatric sufferers.

Promethazine and codeine combination should not be applied to relieve pain following surgical procedure to eliminate tonsils or adenoids in almost any little ones. Significant breathing difficulties and deaths happen to be claimed in a few kids who been given codeine after tonsil or adenoid surgical procedures. Geriatric

When useful for an extended time, this medication might not do the job at the same time and could demand unique dosing. Talk with your physician if this medication stops Operating effectively.

All medications could cause Unintended effects. On the other hand, Many individuals have no Unintended effects or only have insignificant Unwanted side effects. Call your health practitioner or get health-related help if any of those Unwanted effects or any other Unintended effects bother you or don't disappear: Feeling sleepy. Dizziness. Experience nervous and excitable. Constipation.

The existence of other clinical challenges may possibly influence the use of this medicine. You should definitely explain to your medical professional In case you have every other medical problems, Primarily:

The impact of promethazine and/or codeine within the later development and advancement in the newborn is unidentified.

Codeine has good antitussive action, Despite the fact that below that of morphine at equal doses. It's Employed in choice to morphine, because Negative effects are infrequent at the same old antitussive dose of codeine.

Since recurrences of NMS have already been documented with phenothiazines, the reintroduction of promethazine HCl really should be carefully regarded as.

Don't take two doses at the same time or extra doses. Again and again Promethazine VC/Codeine (promethazine, phenylephrine, and codeine) is taken on an as essential basis. Will not get more generally than informed via the health practitioner.

The concomitant use of opioids with other prescription drugs that have an impact on the serotonergic neurotransmitter program has resulted in serotonin syndrome.

Because these reactions could possibly be website claimed voluntarily from the population of unsure sizing, It's not generally probable to reliably estimate their frequency or set up a causal marriage to drug exposure.